~70%
of T2D risk is attributable to heritable factors.¹
Type 2 Diabetes Integrated Risk
Combines in genetic insights from whole-genome sequencing with clinical inputs from an individual's health history, to deliver a more comprehensive and personalized assessment of type 2 diabetes (T2D) risk.
Why it matters
Risk the standard workup does not capture
1 in 3
American adults have prediabetes — and most are undiagnosed.²
58%
reduction in T2D incidence when adults at high risk for T2D adopted intensive lifestyle intervention, highlighting the power of proactive recommendations.³
1. Bonnefond A, Florez JC, et al. Monogenic and polygenic contributions to type 2 diabetes. Lancet Diabetes Endocrinol. 2025. 2. Centers for Disease Control and Prevention. National Diabetes Statistics Report. 3. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393–403.
What goes into the score
Genetics integrated with clinical risk factors
Genetic analysis of approximately 1.3 million markers is integrated with the clinical risk factors below to produce a personalized absolute risk estimate.
Genetic risk factors analyzed by WGS:
- ~1.3M disease risk factors identified in GWAS studies of >180K patients with T2D
- Thousands of ancestry markers, producing a cross-ancestry PRS that accurately stratifies risk across diverse populations
Clinical risk factors integrated:
- Current age
- Sex
- Body mass index
- Family history of type 2 diabetes
- Blood pressure and treatment
- Fasting glucose or HbA1c, when available
Who it's for
Eligibility, turnaround times, and sample types
Eligibility
Adults aged 35–70 with no personal history of type 2 diabetes who are not using insulin or oral antidiabetic medication.
Turnaround times
From samples received, most results are delivered in 5 to 6 weeks. Follow-up testing or re-requisitions for existing MyOme patients are typically completed in under 2 weeks, often within a few days.
Sample Types Accepted
- Blood
- Buccal (cheek swab)
Test codes
Atlas Cardiometabolic PlusPR41027
Atlas Cardiometabolic SelectPR42023
Turnaround times are estimates and begin once samples are processed at MyOme. They may be extended in cases outside MyOme's control, including delays related to confirmation testing or other unforeseen circumstances.
Ordering
Two Ordering Options
This test can be ordered as part of the Atlas Cardiometabolic Plus or Atlas Cardiometabolic Select offerings, depending on your needs.
Atlas Cardiometabolic Plus
Whole-genome sequencing for comprehensive insights across coding and non-coding regions.
Atlas Cardiometabolic Select
High-coverage exome plus low-coverage whole-genome sequencing — a cost-effective option for preventative health decisions.
Interpreting results
Implications for prevention
Increased risk results can inform proactive recommendations aligned with clinical guidelines, such as healthy lifestyle habits, anti-diabetic medication, and regular glucose checks.
Intensive lifestyle intervention and metformin both reduce progression to diabetes in high-risk adults — the score identifies who to prioritize. Providers should weigh personal and family history alongside the score.
Representative report page — not an actual patient result.
Important considerations
What Integrated Risk tests can and cannot tell you
This test is a screening tool, not a diagnostic test.
This test does not detect high-risk variants linked to monogenic conditions (e.g., MODY).
The Integrated Risk test is intended as a screening tool — some people with a high risk score will not develop type 2 diabetes and some with a low risk score will.
Map your risk, guide lifelong health.
We're here at every step — from ordering and sample collection to interpreting results with your patients.