~50%
of CAD risk is due to heritable factors, many of which can be detected as genetic markers by this test.¹
Coronary Artery Disease Integrated Risk
Combines genetic, clinical, and lifestyle factors to calculate a personalized, absolute 10-year risk score of experiencing a CAD-related event.
Why it matters
Detect risk often missed by standard clinical tools
~20%
of cardiac events happen in individuals without standard clinical factors.²
~10%
of patients classified below high-risk by a standard CAD risk calculator* were upgraded to high-risk by MyOme testing.³
1. McPherson R, Tybjaerg-Hansen A. Genetics of CAD. Circulation Research. 2016;118(4). 2. Mazhar J, Figtree G, Vernon ST, et al. Am J Prev Cardiol. 2020;4:100116. 3. Ratman D, Tshiaba P, Levin M, et al. npj Cardiovasc Health. 2025;2:13. *Standard CAD risk calculator refers to the ASCVD pooled cohort equation (PCE) tool.
HOW AN INTEGRATED RISK SCORE IS CALCULATED
Genetics integrated with clinical risk factors
Genetic analysis is integrated with the clinical risk factors below to produce an absolute 10-year and remaining lifetime risk estimate.
Genetic risk factors analyzed by WGS:
- >6M disease risk factors identified in GWAS studies of >150K patients with CAD
- Thousands of ancestry markers, producing a cross-ancestry PRS that accurately stratifies risk across diverse populations
Clinical risk factors integrated:
- It is integrated with ASCVD-PCE to sharpen 10-year and lifetime risk estimates rather than replace them.
- Top-percentile polygenic risk approaches monogenic-level risk — and is far more common in the population.¹
1. Khera, Amit V., et al. "Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations." Nature Genetics 50.9 (2018): 1219–1224.
Clinical risk factors analyzed*
- Current age
- Sex
- Total and HDL cholesterol
- Systolic blood pressure
- Blood pressure treatment
- Diabetes status
- Smoking status
- Body mass index
*Clinical risk factors are based on those included in the ASCVD pooled cohort equation (PCE).
Who it's for
Eligibility, turnaround times, and sample types
Eligibility
Adults aged 40–79 with no personal history of CAD who have all the clinical factors required to calculate risk, as defined by the ASCVD pooled cohort equation (PCE) tool.
Turnaround times
From samples received, most results are delivered in 5 to 6 weeks. Follow-up testing or re-requisitions for existing MyOme patients are typically completed in under 2 weeks, often within a few days.
Sample Types Accepted
- Blood
- Buccal (cheek swab)
Test codes
Atlas Cardiometabolic PlusPR41016
Atlas Cardiometabolic SelectPR42014
Turnaround times are estimates and begin once samples are processed at MyOme. They may be extended in cases outside MyOme's control, including delays related to confirmation testing or other unforeseen circumstances.
Ordering
Two Ordering Options
This test can be ordered as part of the Atlas Cancer Plus or Atlas Cancer Select offerings, depending on your needs.
Atlas Cardiometabolic Plus
Whole-genome sequencing for comprehensive insights across coding and non-coding regions.
View the technical one-pagerAtlas Cardiometabolic Select
High-coverage exome plus low-coverage whole-genome sequencing — a cost-effective option for preventative health decisions.
View the technical one-pagerInterpreting results
Implications for prevention
Elevated risk results can inform proactive recommendations aligned with clinical guidelines, such as cholesterol-lowering treatment, further screening, and a heart-healthy lifestyle.
Representative report page — not an actual patient result.
Important considerations
What this test can and cannot tell you
This test is a screening tool, not a diagnostic test.
This test does not detect high-risk variants linked to monogenic conditions (e.g., familial hypercholesterolemia). MyOme Atlas Curated Screen offers risk screening for certain monogenic cardiometabolic conditions.
The Integrated Risk test is intended as a screening tool — some people with a high risk score will not develop CAD and some with a low risk score will.
Learn more
Coronary Artery Disease Resources
Map your risk, guide lifelong health.
We're here at every step — from ordering and sample collection to interpreting results with your patients.